Type and frequency of drug resistance mutations detected in 23 samples of HIV-positive FSWs with virological failure who remained on ART for at least 6 months
Mutations | n (%) |
Resistance category (n=28) | |
Sequences with any SDRM | 23 (82.1) |
PR sequences with any PI SDRM | 1 (3.6) |
RT sequences with any NRTI SDRM | 16 (57.1) |
RT sequences with any NNRTI SDRM | 23 (82.1) |
RT sequences with any NRTI + any NNRTI SDRM | 16 (57.1) |
PRRT sequences with any NRTI + any NNRTI + PI SDRM | 1 (3.6) |
NRTI-related mutations (n=23) | |
M184V | 16 (70) |
T215Y | 6 (26) |
K65R | 3 (13) |
L74V | 3 (13) |
M41L | 3 (13) |
D67N | 2 (9) |
K219Q | 2 (9) |
L210W | 1 (4) |
K70R | 1 (4) |
NNRTI-related mutations (n=23) | |
K103N | 15 (65) |
G190A | 7 (30) |
P225H | 6 (26) |
K101E | 5 (22) |
Y181C | 4 (17) |
V106M | 1 (4) |
V179F | 1 (4) |
L100I | 1 (4) |
PI-related mutations (n=23) | |
M46L | 1 (4) |
ART, antiretroviral therapy; FSWs, female sex workers; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; PR, Protease; PRRT, Protease and Reverse Transcriptase; RT, Reverse Transcriptase; SDRM, surveillance drug resistance mutation.